Cây Bách bệnh có tên khoa học là Eurycoma longifolia Jack, thuộc họ Thanh thất (Simaroubaceae). Cây phân bố phổ biến ở khắp Việt Nam nhưng phổ biến nhất ở miền Trung. Ngoài ra, cây còn phân bố ở vùng khác như Borneo, Campuchia, Lào, Malaya, Myanmar, Philippines, Sumatera, Thái Lan. Trong Y học cổ truyền, dược liệu có tác dụng bổ khí huyết, ôn tỳ thận, được dùng trong các trường hợp khí huyết lưỡng hư, cơ thể yếu mệt, thiếu máu, ăn uống kém, khó tiêu, các bệnh tả, lỵ, các trường hợp sinh dục yếu, dương suy, tảo tiết; bên cạnh đó, còn dùng để chữa cảm mạo, phát sốt, sốt rét, giải độc rượu, tẩy giun. Thành phần hóa học của dược liệu bao gồm canthin-6-one alkaloid, β-carboline alkaloid, quassinoid, quassinoid diterpenoid, Eurycomaoside, tirucallane-type triterpene, dẫn xuất squalene, biphenylneolignan, eurycolactone, laurycolactone, và eurycomalactone. Các tác dụng dược lý của dược liệu từ đó được nghiên cứu chứng minh bao gồm chống sốt rét, chống ung thư, chống đái tháo đường, chống viêm, kích thích tình dục, kháng khuẩn, giải lo âu.
I. Thông tin về dược liệu
- Dược liệu tiếng Việt: Bách Bệnh - Rễ
- Dược liệu tiếng Trung: nan (nan)
- Dược liệu tiếng Anh: nan
- Dược liệu latin thông dụng: Radix Eurycomae Longifoliae
- Dược liệu latin kiểu DĐVN: Radix Eurycomae Longifoliae
- Dược liệu latin kiểu DĐVN: nan
- Dược liệu latin kiểu thông tư: nan
- Bộ phận dùng: Rễ (Radix)
Theo dược điển Việt nam V: nan
Mô tả dược liệu theo thông tư chế biến dược liệu theo phương pháp cổ truyền: nan
Chế biến theo dược điển việt nam V: nan
Chế biến theo thông tư: nan
II. Thông tin về thực vật
Dược liệu Bách Bệnh - Rễ từ bộ phận Rễ từ loài Eurycoma longifolia.
Mô tả thực vật: Cây nhỏ có cành. Lá kép lông chim lẻ gồm 10 đến 36 đôi lá chét, hầu như không có cuống, hình trứng dài, dày, nhẵn hoặc có lông ở mặt dưới. Hoa và bao hoa phủ đầy lông. Quả hạch màu đỏ, nhẵn, hơi thuôn dài, đầu tù và cong, mặt trong có lông thưa và ngắn. Một hạt, trên mặt hạt có nhiều lông ngắn.
Tài liệu tham khảo: “Những cây thuốc và vị thuốc Việt Nam” - Đỗ Tất Lợi Trong dược điển Việt nam, loài Eurycoma longifolia được sử dụng làm dược liệu.
Kingdom: Plantae
Phylum: Tracheophyta
Order: Sapindales
Family: Simaroubaceae
Genus: Eurycoma
Species: Eurycoma longifolia
Phân bố trên thế giới: Thailand, nan, Myanmar, Philippines, Brunei Darussalam, Cambodia, Malaysia, Indonesia, Singapore, Lao People’s Democratic Republic, Viet Nam
Phân bố tại Việt nam: Dak Lak, Khanh Hoa, Thua Thien-Hue, Đồng Nai, Hue Province, Quang Tri, Tay Ninh, Kon Tum, Quảng Nam, Thừa Thiên - Huế, Ninh Thuận, Khánh Hòa
III. Thành phần hóa học
Theo tài liệu của GS. Đỗ Tất Lợi: (1) Nhóm hóa học: canthin-6-one alkaloid, β-carboline alkaloid, quassinoid, quassinoid diterpenoid, Eurycomaoside, tirucallane-type triterpene, dẫn xuất squalene, biphenylneolignan, eurycolactone, laurycolactone, và eurycomalactone (2) Không có đề cập trong các Dược điển trên
Theo cơ sở dữ liệu lotus, loài Eurycoma longifolia đã phân lập và xác định được 266 hoạt chất thuộc về các nhóm Naphthopyrans, Pyrimidine nucleosides, Organooxygen compounds, Benzene and substituted derivatives, Indoles and derivatives, Prenol lipids, Coumarins and derivatives, Furanoid lignans, Stilbenes, Purine nucleosides, Oxolanes, Steroids and steroid derivatives, Indolonaphthyridine alkaloids, Fatty Acyls, Coumarans, Pyridines and derivatives, Harmala alkaloids, Naphthofurans, Phenols trong bảng dưới đây.
| chemicalTaxonomyClassyfireClass | smiles_count |
|---|---|
| Benzene and substituted derivatives | 353 |
| Coumarans | 127 |
| Coumarins and derivatives | 148 |
| Fatty Acyls | 285 |
| Furanoid lignans | 93 |
| Harmala alkaloids | 155 |
| Indoles and derivatives | 24 |
| Indolonaphthyridine alkaloids | 1594 |
| Naphthofurans | 146 |
| Naphthopyrans | 96 |
| Organooxygen compounds | 179 |
| Oxolanes | 99 |
| Phenols | 75 |
| Prenol lipids | 10319 |
| Purine nucleosides | 170 |
| Pyridines and derivatives | 14 |
| Pyrimidine nucleosides | 73 |
| Steroids and steroid derivatives | 4152 |
| Stilbenes | 83 |
Danh sách chi tiết các hoạt chất như sau:
IV. Tác dụng dược lý
Theo tài liệu quốc tế: nan
V. Dược điển Việt Nam V
Soi bột
nan
Vi phẫu
nan
Định tính
nan
Định lượng
nan
Thông tin khác
- Độ ẩm: nan
- Bảo quản: nan
VI. Dược điển Hồng kong
VII. Y dược học cổ truyền
Tên vị thuốc: nan
Tính: nan
Vị: nan
Quy kinh: nan
Công năng chủ trị: nan
Phân loại theo thông tư: nan
Tác dụng theo y dược cổ truyền: nan
Chú ý: nan
Kiêng kỵ: nan
Cấu trúc hóa học của các hoạt chất thuộc nhóm Benzene and substituted derivatives là 4’-[hydroxy(oxiran-2-yl)methyl]-5-(3-hydroxyprop-1-en-1-yl)-2’,3-dimethoxy-[1,1’-biphenyl]-2-ol (LTS0065804), syringic acid (LTS0210036), 1-{4-[4-(3-hydroxyprop-1-en-1-yl)-2-methoxyphenoxy]-3-methoxyphenyl}propane-1,2,3-triol (LTS0171409), (1r,2r)-1-(4-{4-[(1e)-3-hydroxyprop-1-en-1-yl]-2-methoxyphenoxy}-3-methoxyphenyl)propane-1,2,3-triol (LTS0259426), 4’-[(r)-hydroxy((2s)-oxiran-2-yl)methyl]-5-[(1e)-3-hydroxyprop-1-en-1-yl]-2’,3,6’-trimethoxy-[1,1’-biphenyl]-2-ol (LTS0216560), 4’-[(r)-hydroxy((2s)-oxiran-2-yl)methyl]-5-[(1e)-3-hydroxyprop-1-en-1-yl]-2’,3-dimethoxy-[1,1’-biphenyl]-2-ol (LTS0054667), 4’-[hydroxy(oxiran-2-yl)methyl]-5-(3-hydroxyprop-1-en-1-yl)-2’,3,6’-trimethoxy-[1,1’-biphenyl]-2-ol (LTS0012512), 3,4-dihydroxybenzoic acid (LTS0018765), vanillic acid (LTS0229113).
Cấu trúc hóa học của các hoạt chất thuộc nhóm Coumarans là (2s)-7-[(2s)-5-carboxy-2-(prop-1-en-2-yl)-2,3-dihydro-1-benzofuran-7-yl]-2-(prop-1-en-2-yl)-2,3-dihydro-1-benzofuran-5-carboxylic acid (LTS0076345), 7-[5-carboxy-2-(prop-1-en-2-yl)-2,3-dihydro-1-benzofuran-7-yl]-2-(prop-1-en-2-yl)-2,3-dihydro-1-benzofuran-5-carboxylic acid (LTS0152508).
Cấu trúc hóa học của các hoạt chất thuộc nhóm Coumarins and derivatives là scopoletin (LTS0193112), fraxidin (LTS0182118), scopolin (LTS0061811), 6-methoxy-7-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}chromen-2-one (LTS0042457).
Cấu trúc hóa học của các hoạt chất thuộc nhóm Fatty Acyls là 11-hydroxy-2,6,9,15-tetramethyl-13-oxatetracyclo[10.2.1.0²,¹⁰.0⁵,⁹]pentadec-6-ene-3,8,14-trione (LTS0122455), (1s,2r,5s,9s,10s,11r,12r,15r)-11-hydroxy-2,6,9,15-tetramethyl-13-oxatetracyclo[10.2.1.0²,¹⁰.0⁵,⁹]pentadec-6-ene-3,8,14-trione (LTS0076446), (1s,2r,9s,11r,12r,15r)-11-hydroxy-2,6,9,15-tetramethyl-13-oxatetracyclo[10.2.1.0²,¹⁰.0⁵,⁹]pentadec-6-ene-3,8,14-trione (LTS0032311), (1s,2r,5r,9s,10s,11r,12r,15r)-11-hydroxy-2,6,9,15-tetramethyl-13-oxatetracyclo[10.2.1.0²,¹⁰.0⁵,⁹]pentadec-6-ene-3,8,14-trione (LTS0136870).
Cấu trúc hóa học của các hoạt chất thuộc nhóm Furanoid lignans là 4-{4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-(hydroxymethyl)oxolan-2-yl}-2-methoxyphenol (LTS0211349), 4-[(2s,3s,4r)-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-(hydroxymethyl)oxolan-2-yl]-2-methoxyphenol (LTS0196286).
Cấu trúc hóa học của các hoạt chất thuộc nhóm Harmala alkaloids là 3-{9h-pyrido[3,4-b]indol-1-yl}propanoic acid (LTS0071266), 3-{7-methoxy-9h-pyrido[3,4-b]indol-1-yl}propanoic acid (LTS0240424), 1-(methoxymethyl)-9h-pyrido[3,4-b]indole (LTS0125114), methyl 9h-pyrido[3,4-b]indole-1-carboxylate (LTS0143229), pentyl 3-{9h-pyrido[3,4-b]indol-1-yl}propanoate (LTS0067739).
Cấu trúc hóa học của các hoạt chất thuộc nhóm Indoles and derivatives là β-carboline (LTS0263207).
Cấu trúc hóa học của các hoạt chất thuộc nhóm Indolonaphthyridine alkaloids là 9-hydroxycanthin-6-one (LTS0133957), 13-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-3,5,7,9(16),10(15),11,13-heptaen-2-one (LTS0106779), 1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-3,5(16),7,9,11,14-hexaene-2,13-dione (LTS0234932), 9-methoxycanthin-6-one (LTS0254425), 12,13-dimethoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-3,5,7,9(16),10(15),11,13-heptaen-2-one (LTS0182216), canthin-6-one (LTS0216343), 13-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-3,5,7,9(16),10(15),11,13-heptaen-2-one (LTS0028637), 13-hydroxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16),10(15),11,13-hexaen-2-one (LTS0202212), 12-methoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16),10(15),11,13-hexaen-2-one (LTS0184315), 3-(hydroxymethyl)-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-3,5,7,9(16),10(15),11,13-heptaen-2-one (LTS0063491), 13-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16),10(15),11,13-hexaen-2-one (LTS0072172), 13-methoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16),10(15),11,13-hexaen-2-one (LTS0222112), 12-hydroxy-13-methoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-3,5,7,9(16),10(15),11,13-heptaen-2-one (LTS0232884), 3-(hydroxymethyl)-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16),10(15),11,13-hexaen-2-one (LTS0098582), 1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16),10(15),11,13-hexaen-2-one (LTS0102173), 8-hydroxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16),10(15),11,13-hexaen-2-one (LTS0179188), 6-methyl-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-4,7,9(16),10(15),11,13-hexaene-2,3-dione (LTS0034610), (3r,4r)-3,4-dimethoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16),10(15),11,13-hexaen-2-one (LTS0275332), 13-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16),10(15),11,13-hexaen-2-one (LTS0142844), 3,13-dimethoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-3,5,7,9(16),10(15),11,13-heptaen-2-one (LTS0152663), 4-hydroxy-3-methoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-3,5,7,9(16),10(15),11,13-heptaen-2-one (LTS0262949), 10-hydroxycanthin-6-one (LTS0074837), (3r)-3-methoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16),10(15),11,13-hexaen-2-one (LTS0169713), 3-(hydroxymethyl)-13-methoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-3,5,7,9(16),10(15),11,13-heptaen-2-one (LTS0269745), 8-hydroxy-13-methoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16),10(15),11,13-hexaen-2-one (LTS0261408), 13-methoxy-6-methyl-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-4,7,9(16),10(15),11,13-hexaene-2,3-dione (LTS0199958), 3-methoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16),10(15),11,13-hexaen-2-one (LTS0276092), (3r)-3-(hydroxymethyl)-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16),10(15),11,13-hexaen-2-one (LTS0192349), 12-methoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-3,5,7,9(16),10(15),11,13-heptaen-2-one (LTS0195910), 1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-3,5(16),7,9,12,14-hexaene-2,11-dione (LTS0073015), 2-hydroxy-3-methoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-2,5,7,9(16),10(15),11,13-heptaen-4-one (LTS0073592), 8-hydroxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-3,5,7,9(16),10(15),11,13-heptaen-2-one (LTS0069921), 14-hydroxy-13-methoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-3,5,7,9(16),10(15),11,13-heptaen-2-one (LTS0221140), 14-hydroxy-13-methoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16),10(15),11,13-hexaen-2-one (LTS0025654), 3,4-dimethoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16),10(15),11,13-hexaen-2-one (LTS0058383), 5-methoxycanthin-6-one (LTS0119214), 12,13-dimethoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16),10(15),11,13-hexaen-2-one (LTS0135286), methyl nigakinone (LTS0123859), 8-hydroxy-13-methoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-3,5,7,9(16),10(15),11,13-heptaen-2-one (LTS0261774), 11-hydroxycanthin-6-one (LTS0031951), 11-hydroxy-12-methoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-3,5,7,9(16),10(15),11,13-heptaen-2-one (LTS0005682), (3s,4s)-4-hydroxy-3-methoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16),10(15),11,13-hexaen-2-one (LTS0026130), 4-hydroxy-3-methoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16),10(15),11,13-hexaen-2-one (LTS0100427), (3s)-3-(hydroxymethyl)-13-methoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16),10(15),11,13-hexaen-2-one (LTS0019610), 3-(hydroxymethyl)-13-methoxy-1,6-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16),10(15),11,13-hexaen-2-one (LTS0118790).
Cấu trúc hóa học của các hoạt chất thuộc nhóm Naphthofurans là 3,14,15-trihydroxy-2,6,9,13,16-pentamethyl-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadeca-5,7-diene-4,11-dione (LTS0194559), (1r,2r,3s,9r,12s,13r,14r,15r,16r)-3,14,15-trihydroxy-2,6,9,13,16-pentamethyl-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadeca-5,7-diene-4,11-dione (LTS0099960).
Cấu trúc hóa học của các hoạt chất thuộc nhóm Naphthopyrans là (1r,5s,6r,7r,8r,11r,16s,17s,18r)-5,7,8,16,17-pentahydroxy-6,14,18-trimethyl-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁵,¹⁹.0¹³,¹⁸]nonadec-13-ene-4,9-dione (LTS0053176).
Cấu trúc hóa học của các hoạt chất thuộc nhóm Organooxygen compounds là 2,3,4-trihydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)butan-1-one (LTS0176912), p-hydroxybenzaldehyde (LTS0259836), 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-1-one (LTS0074106), (2r,3r)-2,3,4-trihydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)butan-1-one (LTS0194629), 2-hydroxy-1-(4-hydroxy-3-methoxyphenyl)ethanone (LTS0007429), (2r)-2,3-dihydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-1-one (LTS0107804), 2,3-dihydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-1-one (LTS0260010).
Cấu trúc hóa học của các hoạt chất thuộc nhóm Oxolanes là (3e,6s)-6-[(2r,5s)-5-[(2r,2’s,5r,5’r)-5’-[(2s,4e)-6-hydroxy-6-methylhept-4-en-2-yl]-[2,2’-bioxolan]-5-yl]oxolan-2-yl]-2-methylhept-3-en-2-ol (LTS0060217).
Cấu trúc hóa học của các hoạt chất thuộc nhóm Phenols là syringaldehyde (LTS0201406), (1r,2r)-1-(4-hydroxy-3-methoxyphenyl)propane-1,2,3-triol (LTS0263325), guaiacylglycerol (LTS0120388).
Cấu trúc hóa học của các hoạt chất thuộc nhóm Prenol lipids là (1r,4r,5r,6s,7r,8r,11r,13s,17s,18s,19r)-4,5,7,8,17-pentahydroxy-6,14,18-trimethyl-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-ene-9,16-dione (LTS0146930), (1s,2r,3s,5r,9s,10r,11r,12r)-11,12-dihydroxy-3,10-dimethyl-3-[(2s)-3-methyl-5-oxo-2h-furan-2-yl]-6,13-dioxatetracyclo[7.5.0.0¹,⁵.0²,¹²]tetradecan-7-one (LTS0258557), 4,5,7,8,17-pentahydroxy-6,14,18-trimethyl-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-ene-9,16-dione (LTS0117536), (1’r,2r,4’r,5’r,7’r,8’r,11’r,13’s,17’s,18’s,19’r)-4’,5’,7’,8’,17’-pentahydroxy-14’,18’-dimethyl-3’,10’-dioxaspiro[oxirane-2,6’-pentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadecan]-14’-ene-9’,16’-dione (LTS0125102), 1-[5-(3,3-dimethyloxiran-2-yl)-2-hydroxyoxolan-3-yl]-3a,6,6,9a,11a-pentamethyl-1h,2h,3h,5h,5ah,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-one (LTS0039575), (1r,2s,9s,11s,12s,15s)-11-hydroxy-2,6,9,15-tetramethyl-13-oxatetracyclo[10.2.1.0²,¹⁰.0⁵,⁹]pentadeca-4,6-diene-3,8,14-trione (LTS0203228), (1s,2r,3r,6s,7s,8r,9s,12s,13r,14r,15r,16r)-6,8,14,15-tetrahydroxy-2,6,13,16-tetramethyl-3-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadec-4-en-11-one (LTS0074511), 4,5,7,8,16,17-hexahydroxy-6,14,18-trimethyl-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-en-9-one (LTS0174813), 7-chloro-11-hydroxy-2,6,9,15-tetramethyl-13-oxatetracyclo[10.2.1.0²,¹⁰.0⁵,⁹]pentadeca-4,6-diene-3,8,14-trione (LTS0078995), 3,14,15-trihydroxy-1,2,6,13,16-pentamethyl-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadec-5-ene-4,11-dione (LTS0101455), 3,8,12,14,15-pentahydroxy-2,6,13,16-tetramethyl-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadec-5-ene-4,11-dione (LTS0067203), 4,5,6,7,8,17-hexahydroxy-6-(hydroxymethyl)-14,18-dimethyl-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-ene-9,16-dione (LTS0077989), (2s)-2-[(2r,5r)-5-[(2r,2’s,5s,5’s)-5’-[(2r)-2-hydroxy-6-methylhept-5-en-2-yl]-2’-methyl-[2,2’-bioxolan]-5-yl]-5-methyloxolan-2-yl]-6-methylhept-5-en-2-ol (LTS0217694), (1r,2s,3s,7s,8r,9s,12s,13r,14r,15r,16r)-3,8,14,15-tetrahydroxy-2,6,13,16-tetramethyl-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadec-5-ene-4,11-dione (LTS0213748), eurycomanone (LTS0089470), 8’-(acetyloxy)-4’,7’,17’-trihydroxy-14’,18’-dimethyl-9’,16’-dioxo-3’,10’-dioxaspiro[oxirane-2,6’-pentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadecan]-14’-en-5’-yl acetate (LTS0231451), (2s,4r,7r,8r,9r,12r)-7,8,11-trihydroxy-12-(hydroxymethyl)-2,9-dimethyl-2-[(2r)-3-methyl-5-oxo-2h-furan-2-yl]-5-oxatricyclo[6.3.1.0⁴,¹²]dodec-1(11)-ene-6,10-dione (LTS0097399), (1s,3as,5ar,7s,9ar,9bs,11as)-1-[(2s,4r)-4-[(2s)-3,3-dimethyloxiran-2-yl]-4-hydroxybutan-2-yl]-3a,6,6,9a,11a-pentamethyl-1h,2h,3h,5h,5ah,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-ol (LTS0092482), (1s,3as,5as,9ar,9br,11as)-1-[(2s,3s,5r)-5-[(2s)-3,3-dimethyloxiran-2-yl]-2-hydroxyoxolan-3-yl]-3a,6,6,9a,11a-pentamethyl-1h,2h,3h,5h,5ah,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-one (LTS0030076), 8-(acetyloxy)-4,7,17-trihydroxy-6,14,18-trimethyl-9,16-dioxo-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-en-5-yl acetate (LTS0041012), (1r,4r,5r,6r,7r,8r,11r,13s,17s,18s,19r)-4,5,6,7,8,17-hexahydroxy-6-(hydroxymethyl)-14,18-dimethyl-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-ene-9,16-dione (LTS0047601), (1r,2r,3s,5r,8r,9r,11r,12r)-8,9,11,12-tetrahydroxy-3-methyl-3-[(2r)-3-methyl-5-oxo-2h-furan-2-yl]-10-methylidene-6,13-dioxatetracyclo[7.5.0.0¹,⁵.0²,¹²]tetradecan-7-one (LTS0053349), 3,8,14,15-tetrahydroxy-2,6,13,16-tetramethyl-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadec-5-ene-4,11-dione (LTS0110336), (1r,2s,3s,7r,9r,12r,13r,14s,15r,16r,17s)-3,7,12,13,15,16-hexahydroxy-2,6,14,17-tetramethyl-10-oxatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadec-5-ene-4,11-dione (LTS0120037), (5r,7r,8r,11r,13s,16s,17s,18s,19r)-4,5,7,8,16,17-hexahydroxy-14,18-dimethyl-6-methylidene-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-en-9-one (LTS0118526), (1r,2r,3r,6r,7s,8r,9s,12s,13r,14r,15r,16r)-3,6,8,14,15-pentahydroxy-2,6,13,16-tetramethyl-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadec-4-en-11-one (LTS0127516), (1’r,2s,4’r,5’r,7’r,8’r,11’r,13’s,17’s,18’s,19’r)-8’-(acetyloxy)-4’,7’,17’-trihydroxy-14’,18’-dimethyl-9’,16’-dioxo-3’,10’-dioxaspiro[oxirane-2,6’-pentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadecan]-14’-en-5’-yl acetate (LTS0267627), (1r,4r,5r,6s,7r,8r,11r,13s,16s,17s,18s,19r)-4,5,7,8,16,17-hexahydroxy-6,14,18-trimethyl-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-en-9-one (LTS0137783), (1r,4s,5r,6s,7r,8r,11r,13s,17s,18s,19r)-4,5,7,8,17-pentahydroxy-6,18-dimethyl-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-ene-9,16-dione (LTS0184335), (1s,2r,9r,10s,11r,12r,15r)-7-chloro-11-hydroxy-2,6,9,15-tetramethyl-13-oxatetracyclo[10.2.1.0²,¹⁰.0⁵,⁹]pentadeca-4,6-diene-3,8,14-trione (LTS0259298), (1r,4r,7r,11s,13r,18s,19s)-4,5,7,8,17-pentahydroxy-14,18-dimethyl-6-methylidene-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-ene-9,16-dione (LTS0149273), 1-(5,6-dihydroxy-7,7-dimethyloxepan-3-yl)-3a,6,6,9a,11a-pentamethyl-1h,2h,3h,5h,5ah,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-one (LTS0129635), eurycomanone (LTS0136273), (1s,2r,6r,9r,11r,12r,15r)-11-hydroxy-2,6,9,15-tetramethyl-13-oxatetracyclo[10.2.1.0²,¹⁰.0⁵,⁹]pentadec-4-ene-3,8,14-trione (LTS0137748), 3,14-dihydroxy-2,6,13,16-tetramethyl-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadec-5-ene-4,8,11-trione (LTS0170066), (1s,3as,5ar,9ar,9br,11as)-1-[(2r,3s,5r)-5-[(2s)-3,3-dimethyloxiran-2-yl]-2-hydroxyoxolan-3-yl]-3a,6,6,9a,11a-pentamethyl-1h,2h,3h,5h,5ah,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-one (LTS0152633), 4,5,7,8,17-pentahydroxy-14,18-dimethyl-6-methylidene-16-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-en-9-one (LTS0190639), 4,5,6,7,8,16,17-heptahydroxy-6-(hydroxymethyl)-14,18-dimethyl-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-en-9-one (LTS0145243), (2s,4r,7r,8s,12r)-7,8,11-trihydroxy-12-(hydroxymethyl)-2-methyl-2-[(2r)-3-methyl-5-oxo-2h-furan-2-yl]-9-methylidene-5-oxatricyclo[6.3.1.0⁴,¹²]dodec-1(11)-ene-6,10-dione (LTS0153402), 4,5,7,8,17-pentahydroxy-14,18-dimethyl-6-methylidene-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-ene-9,16-dione (LTS0098657), 3,12,13,15,16-pentahydroxy-2,6,14,17-tetramethyl-4,11-dioxo-10-oxatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadec-5-en-8-yl acetate (LTS0252440), (1r,2r,3s,7s,8r,9s,12r,13r,14s,15r,16r,17s)-3,12,13,15,16-pentahydroxy-2,6,14,17-tetramethyl-4,11-dioxo-10-oxatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadec-5-en-8-yl acetate (LTS0250348), (1r,2r,3s,7s,8r,9s,12s,13r,14r,15r,16r)-3,14,15-trihydroxy-2,6,13,16-tetramethyl-4,11-dioxo-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadec-5-en-8-yl acetate (LTS0170107), 1-[4-(3,3-dimethyloxiran-2-yl)-4-hydroxybutan-2-yl]-3a,6,6,9a,11a-pentamethyl-1h,2h,3h,5h,5ah,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-one (LTS0095321), (1r,2s,3s,7s,9r,12s,13r,14r,15r,16s)-3,14,15-trihydroxy-1,2,6,13,16-pentamethyl-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadec-5-ene-4,11-dione (LTS0234394), 3,12,15,16-tetrahydroxy-2,6,14,17-tetramethyl-10-oxatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadec-5-ene-4,11-dione (LTS0117911), (1’r,2s,4’r,5’r,7’r,8’r,11’r,13’s,17’s,18’s,19’r)-4’,5’,7’,17’-tetrahydroxy-14’,18’-dimethyl-9’,16’-dioxo-3’,10’-dioxaspiro[oxirane-2,6’-pentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadecan]-14’-en-8’-yl acetate (LTS0256543), (1r,4r,5r,7r,8r,11r,13s,16s,17s,18s,19r)-4,5,7,8,17-pentahydroxy-14,18-dimethyl-6-methylidene-16-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-en-9-one (LTS0189012), (1r,4r,5r,6s,7r,8r,11r,13s,17s,18s,19r)-8-(acetyloxy)-4,7,17-trihydroxy-6,14,18-trimethyl-9,16-dioxo-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-en-5-yl acetate (LTS0173540), 6,8,14,15-tetrahydroxy-2,6,13,16-tetramethyl-3-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadec-4-en-11-one (LTS0086648), (1r,2s,3s,7s,9r,13s,14r,15s,17s)-3,15-dihydroxy-2,6,14,17-tetramethyl-10-oxatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadec-5-ene-4,11,16-trione (LTS0247389), 4-(acetyloxy)-1,4-bis[5-(2-hydroxy-6-methylhept-5-en-2-yl)-2-methyloxolan-2-yl]butyl acetate (LTS0159549), 4-hydroxy-1,4-bis[5-(2-hydroxy-6-methylhept-5-en-2-yl)-2-methyloxolan-2-yl]butyl acetate (LTS0185912), 3,8,12,13,15,16-hexahydroxy-2,6,14,17-tetramethyl-10-oxatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadec-5-ene-4,11-dione (LTS0223204), (1s,4r)-4-(acetyloxy)-1-[(2r,5r)-5-[(2s)-2-hydroxy-6-methylhept-5-en-2-yl]-2-methyloxolan-2-yl]-4-[(2s,5r)-5-[(2s)-2-hydroxy-6-methylhept-5-en-2-yl]-2-methyloxolan-2-yl]butyl acetate (LTS0268516), 2-{5-[5’-(2-hydroxy-6-methylhept-5-en-2-yl)-2’-methyl-[2,2’-bioxolan]-5-yl]-5-methyloxolan-2-yl}-6-methylhept-5-en-2-ol (LTS0061152), (1r,3as,5ar,9ar,9bs,11as)-1-[(3s)-5-hydroxy-6-(2-hydroxypropan-2-yl)oxan-3-yl]-3a,6,6,9a,11a-pentamethyl-1h,2h,3h,5h,5ah,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-one (LTS0074054), (1r,4r,5r,7r,8r,11r,13s,16s,17s,18s,19r)-4,5,7,8,16,17-hexahydroxy-14,18-dimethyl-6-methylidene-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-en-9-one (LTS0273283), (1s,3as,5ar,9ar,9br,11as)-1-[(2s,4r)-4-[(2s)-3,3-dimethyloxiran-2-yl]-4-hydroxybutan-2-yl]-3a,6,6,9a,11a-pentamethyl-1h,2h,3h,5h,5ah,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-one (LTS0248938), 4,7,8,17-tetrahydroxy-6,14,18-trimethyl-9,16-dioxo-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-en-5-yl acetate (LTS0270732), (1’r,2s,4’r,5’r,7’r,8’r,11’r,13’s,17’s,18’s,19’r)-4’,5’,7’,8’,17’-pentahydroxy-14’,18’-dimethyl-3’,10’-dioxaspiro[oxirane-2,6’-pentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadecan]-14’-ene-9’,16’-dione (LTS0056857), (1r,2s,3s,4s,7s,8r,9s,12s,13r,14r,15r,16r)-3,4,8,14,15-pentahydroxy-2,13,16-trimethyl-6-methylidene-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadecan-11-one (LTS0203308), 7,8,10,11-tetrahydroxy-2,9,12-trimethyl-2-(3-methyl-5-oxo-2h-furan-2-yl)-5-oxatricyclo[6.3.1.0⁴,¹²]dodecan-6-one (LTS0217137), (1r,2s,3s,7s,9r,12r,13s,14r,15r,16r,17s)-3,12,15,16-tetrahydroxy-2,6,14,17-tetramethyl-10-oxatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadec-5-ene-4,11-dione (LTS0085724), 8,9,11,12-tetrahydroxy-3,10-dimethyl-3-(3-methyl-5-oxo-2h-furan-2-yl)-6,13-dioxatetracyclo[7.5.0.0¹,⁵.0²,¹²]tetradecan-7-one (LTS0216308), 11-hydroxy-2,6,9,15-tetramethyl-13-oxatetracyclo[10.2.1.0²,¹⁰.0⁵,⁹]pentadec-4-ene-3,8,14-trione (LTS0098855), (1s,2r,9r,10s,11r,12r,15r)-11-hydroxy-2,6,9,15-tetramethyl-13-oxatetracyclo[10.2.1.0²,¹⁰.0⁵,⁹]pentadeca-4,6-diene-3,8,14-trione (LTS0220847), (1s,2s,3s,7s,8r,9s,12s,13r,14r,15r,16r)-3,8,14,15-tetrahydroxy-2,6,13,16-tetramethyl-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadec-5-ene-4,11-dione (LTS0207646), (3e,6r)-6-[(2r,5s)-5-[(2r,2’s,5r,5’r)-5’-[(2r,4e)-6-hydroperoxy-2-hydroxy-6-methylhept-4-en-2-yl]-2’-methyl-[2,2’-bioxolan]-5-yl]-5-methyloxolan-2-yl]-2-methylhept-3-ene-2,6-diol (LTS0093503), (1s,3as,5ar,9ar,9br,11as)-1-[(3s,5r,6s)-5,6-dihydroxy-7,7-dimethyloxepan-3-yl]-3a,6,6,9a,11a-pentamethyl-1h,2h,3h,5h,5ah,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-one (LTS0215285), (1r,2s,3s,7s,8r,9s,13r,14s,15r,16r)-3,8,14,15-tetrahydroxy-2,6,13,16-tetramethyl-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadec-5-ene-4,11-dione (LTS0230549), 3,7,12,13,15,16-hexahydroxy-2,6,14,17-tetramethyl-10-oxatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadec-5-ene-4,11-dione (LTS0208882), (3e,6s)-6-[(2r,5s)-5-[(2r,2’s,5r,5’r)-5’-[(2s,4e)-6-hydroperoxy-2-hydroxy-6-methylhept-4-en-2-yl]-2’-methyl-[2,2’-bioxolan]-5-yl]-5-methyloxolan-2-yl]-2-methylhept-3-ene-2,6-diol (LTS0221732), (1r,4s,5r,6r,7r,8r,11r,13s,17s,18s,19r)-4,5,7,8,17-pentahydroxy-6,14,18-trimethyl-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-ene-9,16-dione (LTS0182942), (1s,2r,6r,9r,10s,11r,12r,15r)-11-hydroxy-2,6,9,15-tetramethyl-13-oxatetracyclo[10.2.1.0²,¹⁰.0⁵,⁹]pentadec-4-ene-3,8,14-trione (LTS0029558), (1r,2s,3s,7s,9r,13s,14r,15r,17s)-3,15-dihydroxy-2,6,14,17-tetramethyl-10-oxatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadec-5-ene-4,11,16-trione (LTS0017596), (1r,2s,9s,10r,11s,12s,15s)-7-chloro-11-hydroxy-2,6,9,15-tetramethyl-13-oxatetracyclo[10.2.1.0²,¹⁰.0⁵,⁹]pentadeca-4,6-diene-3,8,14-trione (LTS0063026), methyl (1s,2r,8r,9r,10r,11r,12r,15r)-8,11-dihydroxy-2,6,9,15-tetramethyl-3,14-dioxo-13-oxatetracyclo[10.2.1.0²,¹⁰.0⁵,⁹]pentadeca-4,6-diene-8-carboxylate (LTS0232155), (1s,3as,5ar,9ar,9br,11as)-3a,6,6,9a,11a-pentamethyl-1-[(2s,4r,5s)-4,5,6-trihydroxy-6-methylheptan-2-yl]-1h,2h,3h,5h,5ah,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-one (LTS0189980), (1s,4s,5s,6r,7r,8s,11s,13r,17r,18r,19s)-4,5,7,8,17-pentahydroxy-6,14,18-trimethyl-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-ene-9,16-dione (LTS0067341), (1s,2s,3s,7r,9s,12s,13s,14s,16r)-3,14-dihydroxy-2,6,13,16-tetramethyl-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadec-5-ene-4,8,11-trione (LTS0241508), 4’,5’,7’,8’,17’-pentahydroxy-14’,18’-dimethyl-3’,10’-dioxaspiro[oxirane-2,6’-pentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadecan]-14’-ene-9’,16’-dione (LTS0062456), (1s,3as,5as,9ar,9br,11as)-1-[(3s,5r,6s)-5,6-dihydroxy-7,7-dimethyloxepan-3-yl]-3a,6,6,9a,11a-pentamethyl-1h,2h,3h,5h,5ah,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-one (LTS0256502), (1r,2s,3s,7s,9r,12s,13r,14r,15r,16r)-3,14,15-trihydroxy-2,6,13,16-tetramethyl-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadec-5-ene-4,11-dione (LTS0191847), (1r,2s,3s,7s,8r,9s,12r,13s,14r,15r,16s)-3,8,12,14,15-pentahydroxy-2,6,13,16-tetramethyl-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadec-5-ene-4,11-dione (LTS0253703), (1r,2r,3r,6r,7s,8r,9s,12s,13r,14r,15r,16r)-6,8,14,15-tetrahydroxy-2,6,13,16-tetramethyl-3-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadec-4-en-11-one (LTS0256616), (3as,5ar,9ar,9br,11as)-1-[4-(3,3-dimethyloxiran-2-yl)-4-hydroxybutan-2-yl]-3a,6,6,9a,11a-pentamethyl-1h,2h,3h,5h,5ah,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-one (LTS0274890), (1s,3as,5ar,7s,9ar,9br,11as)-1-[(2s,4r)-4-[(2s)-3,3-dimethyloxiran-2-yl]-4-hydroxybutan-2-yl]-3a,6,6,9a,11a-pentamethyl-1h,2h,3h,5h,5ah,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-ol (LTS0269481), 4’,5’,7’,17’-tetrahydroxy-14’,18’-dimethyl-9’,16’-dioxo-3’,10’-dioxaspiro[oxirane-2,6’-pentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadecan]-14’-en-8’-yl acetate (LTS0011735), (1r,2s,3s,7s,9r,12r,13r,14s,15r,16r,17s)-3,12,13,15,16-pentahydroxy-2,6,14,17-tetramethyl-10-oxatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadec-5-ene-4,11-dione (LTS0115850), (1r,2s,3s,7s,9r,12r,13r,14s,15r,16r,17s)-3,13,15,16-tetrahydroxy-2,6,14,17-tetramethyl-4,11-dioxo-10-oxatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadec-5-en-12-yl acetate (LTS0123998), (1r,4r,5r,7r,8r,11r,13s,17s,18s,19r)-4,5,7,8,17-pentahydroxy-14,18-dimethyl-6-methylidene-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-ene-9,16-dione (LTS0121207), (1r,4r,5r,6s,7r,8r,11r,13s,17s,18s,19r)-4,7,8,17-tetrahydroxy-6,14,18-trimethyl-9,16-dioxo-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-en-5-yl acetate (LTS0260838), (1r,2r,3s,7s,8r,9s,12r,13s,14r,15r,16r,17s)-3,12,15,16-tetrahydroxy-2,6,14,17-tetramethyl-4,11-dioxo-10-oxatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadec-5-en-8-yl acetate (LTS0063049), 3,13,15,16-tetrahydroxy-2,6,14,17-tetramethyl-4,11-dioxo-10-oxatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadec-5-en-12-yl acetate (LTS0015458), (1s,2s,3r,5s,8s,9s,10r,11s,12s)-8,9,11,12-tetrahydroxy-3,10-dimethyl-3-[(2r)-3-methyl-5-oxo-2h-furan-2-yl]-6,13-dioxatetracyclo[7.5.0.0¹,⁵.0²,¹²]tetradecan-7-one (LTS0032687), 6-{5-[5’-(6-hydroperoxy-2-hydroxy-6-methylhept-4-en-2-yl)-2’-methyl-[2,2’-bioxolan]-5-yl]-5-methyloxolan-2-yl}-2-methylhept-3-ene-2,6-diol (LTS0010122), 3,14,15-trihydroxy-2,6,13,16-tetramethyl-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadec-5-ene-4,11-dione (LTS0129805), (1s,3as,5as,9ar,9br,11as)-1-[(2s,4r)-4-[(2s)-3,3-dimethyloxiran-2-yl]-4-hydroxybutan-2-yl]-3a,6,6,9a,11a-pentamethyl-1h,2h,3h,5h,5ah,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-one (LTS0005566), (1’r,2s,4’s,5’r,7’r,8’r,11’r,13’s,17’s,18’s,19’r)-4’,5’,7’,8’,17’-pentahydroxy-14’,18’-dimethyl-3’,10’-dioxaspiro[oxirane-2,6’-pentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadecan]-14’-ene-9’,16’-dione (LTS0003405), (1s,3as,5as,9ar,9br,11as)-3a,6,6,9a,11a-pentamethyl-1-[(2s,4r,5s)-4,5,6-trihydroxy-6-methylheptan-2-yl]-1h,2h,3h,5h,5ah,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-one (LTS0000660), 3,12,13,15,16-pentahydroxy-2,6,14,17-tetramethyl-10-oxatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadec-5-ene-4,11-dione (LTS0054526), 3,14,15-trihydroxy-2,6,13,16-tetramethyl-4,11-dioxo-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadec-5-en-8-yl acetate (LTS0092696), 3,15-dihydroxy-2,6,14,17-tetramethyl-10-oxatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadec-5-ene-4,11,16-trione (LTS0025551), (1r,2s,4r,7r,8r,9s,10r,11r,12s)-7,8,10,11-tetrahydroxy-2,9,12-trimethyl-2-[(2r)-3-methyl-5-oxo-2h-furan-2-yl]-5-oxatricyclo[6.3.1.0⁴,¹²]dodecan-6-one (LTS0108866), (2s,4r,7r,8r,9s,12r)-7,8,11-trihydroxy-12-(hydroxymethyl)-2,9-dimethyl-2-[(2r)-3-methyl-5-oxo-2h-furan-2-yl]-5-oxatricyclo[6.3.1.0⁴,¹²]dodec-1(11)-ene-6,10-dione (LTS0241734), 3a,6,6,9a,11a-pentamethyl-1-(4,5,6-trihydroxy-6-methylheptan-2-yl)-1h,2h,3h,5h,5ah,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-one (LTS0097158), (1s,4s,5s,6r,7s,8s,11s,13r,17r,18r,19s)-4,5,7,8,17-pentahydroxy-6,14,18-trimethyl-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-ene-9,16-dione (LTS0228534), 11-hydroxy-2,6,9,15-tetramethyl-13-oxatetracyclo[10.2.1.0²,¹⁰.0⁵,⁹]pentadeca-4,6-diene-3,8,14-trione (LTS0246149), 3,12,15,16-tetrahydroxy-2,6,14,17-tetramethyl-4,11-dioxo-10-oxatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadec-5-en-8-yl acetate (LTS0109996), 1-[4-(3,3-dimethyloxiran-2-yl)-4-hydroxybutan-2-yl]-3a,6,6,9a,11a-pentamethyl-1h,2h,3h,5h,5ah,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-ol (LTS0041689), 4,5,7,8,16,17-hexahydroxy-14,18-dimethyl-6-methylidene-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-en-9-one (LTS0037159), (1r,2s,3s,7s,8r,9s,12r,13r,14s,15r,16r,17s)-3,8,12,13,15,16-hexahydroxy-2,6,14,17-tetramethyl-10-oxatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadec-5-ene-4,11-dione (LTS0091295), (1r,4r,5r,6r,7r,8r,11r,13s,16s,17s,18s,19r)-4,5,6,7,8,16,17-heptahydroxy-6-(hydroxymethyl)-14,18-dimethyl-3,10-dioxapentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadec-14-en-9-one (LTS0274084), (1s,4r)-4-hydroxy-1-[(2r,5r)-5-[(2s)-2-hydroxy-6-methylhept-5-en-2-yl]-2-methyloxolan-2-yl]-4-[(2s,5r)-5-[(2s)-2-hydroxy-6-methylhept-5-en-2-yl]-2-methyloxolan-2-yl]butyl acetate (LTS0126627), (1s,2r,3s,7s,8r,9s,12s,13r,14r,15r,16r)-3,14,15-trihydroxy-2,6,13,16-tetramethyl-4,11-dioxo-10-oxatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadec-5-en-8-yl acetate (LTS0124471), (1’r,2s,5’r,7’r,8’r,11’r,13’s,17’s,18’s,19’r)-4’,5’,7’,8’,17’-pentahydroxy-14’,18’-dimethyl-3’,10’-dioxaspiro[oxirane-2,6’-pentacyclo[9.8.0.0¹,⁷.0⁴,¹⁹.0¹³,¹⁸]nonadecan]-14’-ene-9’,16’-dione (LTS0245932), methyl 8,11-dihydroxy-2,6,9,15-tetramethyl-3,14-dioxo-13-oxatetracyclo[10.2.1.0²,¹⁰.0⁵,⁹]pentadeca-4,6-diene-8-carboxylate (LTS0265489).
Cấu trúc hóa học của các hoạt chất thuộc nhóm Purine nucleosides là adenosine (LTS0052576), 2-(6-hydroxy-2-imino-3h-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol (LTS0005186), adenosine (LTS0014061), ribonucleoside (LTS0044502).
Cấu trúc hóa học của các hoạt chất thuộc nhóm Pyridines and derivatives là niacin (LTS0216673).
Cấu trúc hóa học của các hoạt chất thuộc nhóm Pyrimidine nucleosides là thymidine (LTS0162810), 4-hydroxy-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one (LTS0253531).
Cấu trúc hóa học của các hoạt chất thuộc nhóm Steroids and steroid derivatives là (1r,2s,3s,5r,9r,10r,11r,12s,13s,16s)-3,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-6-ene-8,15-dione (LTS0064119), (2r,5s,9s,10s,11r,12r,13r,16r)-9,12-dihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-6-ene-3,8,15-trione (LTS0065364), (1r,2r,3s,5r,9r,10r,11s,12r,13s,16r)-3,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-6-ene-8,15-dione (LTS0198774), (1s,2r,6s,8s,9s,10r,12r,13r,16r)-6,8,9,12-tetrahydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-4-ene-3,15-dione (LTS0124050), 4,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-6-ene-3,8,15-trione (LTS0194385), eurycomalactone (LTS0059455), (1s,2r,8s,9s,10r,11r,12r,13r,16r)-8,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadeca-4,6-diene-3,15-dione (LTS0076660), (1s,2r,9s,10r,11r,12r,13r,16r)-4,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadeca-4,6-diene-3,8,15-trione (LTS0072722), (1s,2r,5s,8s,9s,10s,11r,12r,13r,16r)-8,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-6-ene-3,15-dione (LTS0091890), (1r,2r,4s,5r,8s,9r,10s,11s,12r,13s,16s)-4,8,9,12-tetrahydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-6-ene-3,15-dione (LTS0102063), 9,10,13-trihydroxy-2,6,11,17-tetramethyl-7,15-dioxapentacyclo[12.2.1.0²,¹².0⁵,¹¹.0⁶,⁸]heptadec-4-ene-3,16-dione (LTS0041485), (1s,2r,3r,8s,9s,10r,11s,12r,13r,16r)-3,8,9,12-tetrahydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-5-ene-4,15-dione (LTS0187034), 8,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-6-ene-3,15-dione (LTS0194225), (1r,2s,5s,9r,10r,11s,12s,13s,16s)-5,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-6-ene-3,8,15-trione (LTS0113537), (1s,2r,9s,10r,11r,12r,13r,16r)-9,12-dihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadeca-4,6-diene-3,8,15-trione (LTS0198988), sitogluside (LTS0201798), 9,12-dihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadeca-4,6-diene-3,8,15-trione (LTS0150202), (1r,2s,5r,8r,9r,10r,11s,12s,13s,16s)-8,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-6-ene-3,15-dione (LTS0134247), 9,12-dihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-6-ene-3,8,15-trione (LTS0151999), (1r,2s,8s,9r,10r,11r,12r,13s,16r)-8,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadeca-4,6-diene-3,15-dione (LTS0145080), 10,13-dihydroxy-2,6,11,17-tetramethyl-7,15-dioxapentacyclo[12.2.1.0²,¹².0⁵,¹¹.0⁶,⁸]heptadec-4-ene-3,9,16-trione (LTS0225517), (1s,2r,8s,9s,10s,11r,12r,13r,16r)-8,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-6-ene-3,15-dione (LTS0223997), 2-{[1-(5-ethyl-6-methylheptan-2-yl)-9a,11a-dimethyl-1h,2h,3h,3ah,3bh,4h,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol (LTS0158828), 8,9,12-trihydroxy-2,10,16-trimethyl-6-methylidene-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadecane-3,15-dione (LTS0211819), (1r,2s,9r,10s,11s,12s,13s,16s)-9,12-dihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadeca-4,6-diene-3,8,15-trione (LTS0173448), 4,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadeca-4,6-diene-3,8,15-trione (LTS0060030), (1s,2r,4r,5s,9s,10r,11r,12r,13r,16r)-4,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-6-ene-3,8,15-trione (LTS0218349), (1r,2s,6r,8s,9s,10r,11s,12s,13s,14s,17s)-9,10,13-trihydroxy-2,6,11,17-tetramethyl-7,15-dioxapentacyclo[12.2.1.0²,¹².0⁵,¹¹.0⁶,⁸]heptadec-4-ene-3,16-dione (LTS0254360), (1r,2s,5r,9r,10r,11s,12s,13s,16s)-9,12-dihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-6-ene-3,8,15-trione (LTS0239199), 5,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-6-ene-3,8,15-trione (LTS0215384), 12-hydroxy-2,6,10,16-tetramethyl-9,14-dioxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadeca-4,6-diene-3,8,15-trione (LTS0166752), (1r,2s,6s,8s,10r,11s,12s,13s,14s,17s)-10,13-dihydroxy-2,6,11,17-tetramethyl-7,15-dioxapentacyclo[12.2.1.0²,¹².0⁵,¹¹.0⁶,⁸]heptadec-4-ene-3,9,16-trione (LTS0240061), 3,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-6-ene-8,15-dione (LTS0022366), phytosterol (LTS0029311), 8,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-4-ene-3,15-dione (LTS0246426), stigmasterol (LTS0024262), (1r,2r,6s,8s,9r,10r,11s,12r,13s,16s)-8,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-4-ene-3,15-dione (LTS0259280), (1s,2r,3r,5s,9s,10s,11s,12r,13r,16r)-3,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-6-ene-8,15-dione (LTS0253883), (1s,2r,10r,11r,12r,13r,16r)-12-hydroxy-2,6,10,16-tetramethyl-9,14-dioxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadeca-4,6-diene-3,8,15-trione (LTS0048808), (1r,2r,5r,8r,9r,10r,11s,12r,13s,16s)-8,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-6-ene-3,15-dione (LTS0062065), campesterol (LTS0046755), (1r,2r,4s,5s,9r,10r,11r,12r,13s,16s)-4,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-6-ene-3,8,15-trione (LTS0246387), (1r,2s,6s,8r,9r,10s,11s,12s,13s,16s)-8,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-4-ene-3,15-dione (LTS0005421), (1s,2r,4r,5s,8s,9s,10r,11r,12r,13r,16r)-4,8,9,12-tetrahydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-6-ene-3,15-dione (LTS0033172), (1r,2s,8r,9r,10s,11s,12s,13s,16s)-8,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadeca-4,6-diene-3,15-dione (LTS0010032), (1r,3ar,3br,7s,9ar,9br,11ar)-1-[(2r,5r)-5,6-dimethylheptan-2-yl]-9a,11a-dimethyl-1h,2h,3h,3ah,3bh,4h,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-ol (LTS0015450), 8,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadeca-4,6-diene-3,15-dione (LTS0015030), 3,8,9,12-tetrahydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-5-ene-4,15-dione (LTS0094060), 4,8,9,12-tetrahydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-6-ene-3,15-dione (LTS0041206), (1s,2r,6r,8s,9s,10r,12r,13r,16r)-8,9,12-trihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadec-4-ene-3,15-dione (LTS0245456), (1r,3ar,3br,7s,9ar,9br,11ar)-1-[(2s,3e,5s)-5-ethyl-6-methylhept-3-en-2-yl]-9a,11a-dimethyl-1h,2h,3h,3ah,3bh,4h,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-ol (LTS0244733), (1r,2s,5r,8r,9r,10r,11s,12s,13s,16s)-8,9,12-trihydroxy-2,10,16-trimethyl-6-methylidene-14-oxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadecane-3,15-dione (LTS0019666).
Cấu trúc hóa học của các hoạt chất thuộc nhóm Stilbenes là 1,2-diguaiacylpropane-1,3-diol (LTS0243974), (1s,2s)-1,2-bis(4-hydroxy-3-methoxyphenyl)propane-1,3-diol (LTS0040718).